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Frederick L. Altice, M.D.
blue arrow Professor of Medicine, Internal Medicine, Infectious Diseases
blue arrow Director, Clinical and Community Research
blue arrow Director, HIV in Prisons Program
blue arrow Director, Community Health Care Van
blue arrow Investigator, Clinical and Health Services Research (CHSR) Core

Contact:
blue arrow frederick.altice@yale.edu
blue arrow Ph: (203) 737-2883
 Frederick L. Altice


Brief Bio:
Frederick L. Altice, MD, is Professor of Medicine at Yale University School of Medicine in New Haven, Connecticut. He is the Director of Clinical and Community Research of the Yale University AIDS Program for the School of Medicine, where he also directs the Community Health Care Van and the HIV in Prisons Program.

Dr. Altice's research interests are focused on the interface between infectious diseases and substance abuse. As a clinical epidemiologist, health services and intervention researcher, he has created novel programs for the treatment of HIV, HCV, and tuberculosis in vulnerable populations, including injection drug users and prison inmates. Specifically, he has been an international leader in research related to adherence to antiretroviral therapy, particularly among HIV+ drug users, has made considerable inroads into novel approaches using directly administered antiretroviral therapy and other structural interventions to facilitate adherence both nationally and internationally.

Dr. Altice has been at the forefront of integrating buprenorphine and methadone treatment into managing co-morbid conditions, including the management of HIV, HCV, TB and mental illness. He is the Principal Investigator on over 15 federally-funded grants, including numerous clinical investigations funded by the National Institutes on Health, the Substance Abuse and Mental Health Services Administration, Special Projects of National Significance for the Health Resources Services Agency and other federal agencies, Dr. Altice is currently leading studies that bridge the gap between the correctional and community setting, specifically on the use of directly observed antiretroviral therapy and opiate-substitution therapy. In addition to publishing his research in peer-reviewed journals, Dr. Altice has authored several significant books and book chapters. He lectures nationally and internationally on the subject of HIV, viral hepatitis, substance abuse and the management of medically complicated patients.

Current research includes methadone and buprenorphine as primary and secondary HIV prevention, directly administered antiretroviral therapy, peer-driven interventions, secondary prevention among drug users and prisoners and includes international projects in Malaysia, Ukraine and Iran.

Areas of Expertise:
Addiction Medicine,Addiction Treatment,Buprenorphine,Criminal Justice,HCV and HBV Treatment,Health Outcomes Research,Health Services Research,HIV prevention,HIV Treatment,Infectious Diseases,Injection Drug Use,International Health,Intervention Development,Mental Illness,Methadone,Patient and Physician Counseling,Prisons/Prison population,Treatment Adherence,Tuberculosis,Vulnerable Populations

CIRA Affiliated Projects:
Alcohol Pharmacotherapies Among Released Prisoners
Funder:
National Institute on Alcohol Abuse and Alcoholism
Status: Active
Region:
U.S. - Connecticut
Direct/Observed Therapy/Community-Released HIV+Prisoners
Funder:
National Institute on Drug Abuse
Status: Active
Region:
U.S. - Connecticut
Improving Health Outcomes for Released HIV+ Prisoners
Funder:
National Institute on Drug Abuse
Status: Active
Region:
U.S. - Connecticut
Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
Funder:
National Institute on Drug Abuse
Status: Active
Region:
Southeast Asia
Project CHOICES: Targeted Capacity Expansion Program for Substance Abuse Treatment and HIV/AIDS
Funder:
Center for Substance Abuse Treatment
Status: Active
Region:
U.S. - Connecticut
Project TRANSITIONS: Enhancing Linkages to HIV Primary Care in Jail Settings
Funder:
Health Resources and Services Administration
Status: Active
Region:
U.S. - Connecticut
Buprenorphine Treatment Expansion in HIV Clinical Settings
Funder:
Center for Substance Abuse Treatment
Status: Completed
Region:
U.S. - Connecticut
HIV Prevention Research with HIV+ Incarcerated Populations
Funder:
National Center for HIV, Viral Hepatitis, STDs and TB Prevention
Status: Completed
Region:
U.S. - Connecticut
Increasing Drug Users' Adherence to HIV Therapeutics
Funder:
National Institute on Drug Abuse
Status: Completed
Region:
U.S. - Connecticut
Integrating Buprenorphine into HIV Clinical Care Settings
Funder:
Health Resources and Services Administration
Status: Completed
Region:
U.S. - Connecticut
Project TRUST: Directly Observed Anti-Retroviral Therapy Among Active Drug Users
Funder:
National Institute on Drug Abuse
Status: Completed
Region:
U.S. - Connecticut

Selected Publications:
In Press

Smith-Rohrberg Maru D, Springer SA, Gunneberg C,Thomas K, Tyndall M, Lezhentsev K, Kamarulzaman A, Altice FL.  (In Press). Interventions to Improve Adherence to Medical Therapeutics for Drug Users: Review and Policy Analysis. PLoS Medicine, (), .

2009

Copenhaver, M., Altice, F.L.  (2009). Adaptation of an evidence -based intervention targeting HIV -Infected prisoners transitioning to the community: The process and outcome of formative research the Positive Living Using Dafety (PLUS) intervention. AIDS Patient Care & STDs, 23(4), 277-87.

Springer, S.A., Chen, S., Altice, F.L.  (2009). Depression and symptomatic response among HIV-infected drug users enrolled in a randomized controlled trial of directly administered antiretroviral therapy. AIDS Care, 21(8), 976-983.

Gupta, S., Altice, F.L.  (2009). Hepatitis B Virus Infection in US Correctional facilities: A Review of Diagnosis, Management, and Public Health Implications. Journal of Urban Health, 86(2), 263-279.

Bruce, R.D., Govindasamy, S., Sylla, L.N., Kamarulzaman, A., Altice, F.L.  (2009). Lack of Reduction in Buprenorphine Injection After Introduction of Co-formulated Buprenorphine/Naloxone to the Malaysian Market. American Journal of Drug & Alcohol Abuse, 35(2), 68-72.

Maru, D.S.R., Bruce, R.D., Walton, M., Springer, S.A., Altice, F.L.  (2009). Persistence of Virological Benefits Following Directly Administered Antiretroviral Therapy among Drug Users: Results from a Randomized, Controlled Trial. Journal Of AIDS, 50(2), 176-181.

2008

Bruce, R.D., Govindasamy, S. Sylla, L.N., Kamarulzaman, A., Altice, F.L.  (2008). Case Series of Buprenorphine Injectors in Kuala Lumpur, Malaysia. American Journal of Drug & Alcohol Abuse, 34(4), 511-517.

Smith-Rohrberg Maru, D., Bruce, R.D., Basu, S., Altice, F.L.  (2008). Clinical Outcomes of Hepatitis C Treatment in a Prison Setting: Feasibility and Effectiveness for Challenging Treatment Populations. Clinical Infectious Diseases, 47(7), 952-961.

Altice, F.L.  (2008, ). Policy Guidelines for Collaborative TB and HIV Services for Injecting and Other Drug Users: An Integrated Approach. World Health Organization (WHO), pp. .

2007

Springer, A.D., Friedland, G.H., Doros, G., Pesanti, E., Altice, F.L.  (2007). Antiretroviral Treatment Regimen outcomes Among HIV-Infected Prisoners. HIV Clinical Trials, 8(4), 205-212.

Copenhaver, M.M., Bruce, R.D., Altice, F.L.  (2007). Behavioral counseling content for optimizing the use of buprenorphine for opoid dependence in community-based settings: A review of the empirical evidence. American Journal of Drug & Alcohol Abuse, 33(5), 643-54.

Bruce, R.D., Altice, F.L.  (2007). Clinical Care of the HIV-Infected Drug User. Infectious Disease Clinics of North America, 21(1), 149-179.

Maru, D.S.R., Kozal, M.J., Bruce, R.D., Springer, S.A., Shield, D.S., Altice, F.L.  (2007). Directly Administered Antiretroviral Therapy for HIV-Infected Drug Users Does Not Have an Impact on Antiretroviral Resistance: Results From A Randomized Controlled Trial. Journal Of AIDS, 46(5), 555-563.

Bruce, R.D., Dvoryak, S., Sylla, L.N., Altice, F.L.  (2007). HIV Treatment access and scale up for delivery for Injection Drug Users in Ukraine for Opiate Substitution Therapy with Buprenorphine: Program Description and Policy Implications. International Journal of Drug Policy, 18(4), 326-8.

Maru, D.S., Bruce, R.D., Walton, M., Mezger, J.A., Springer, S.A., Shield, D., Altice, F.L.  (2007). Initiation, Adherence, and Retention in a Randomized Controlled Trial of Directly Administered Antiretroviral Therapy. AIDS and Behavior, 11(7), 946-57.

Sylla, L.N., Bruce, R.D., Kamarulzaman, A., Altice, F.L.  (2007). Integration and Co-Location of HIV/AIDS, Tuberculosis and Substance Abuse Treatment Services: Paradigms for Complex Patient Populations. International Journal of Drug Policy, 18(), 306-12.

Safren, S.A., Wingood, G., Altice, F.L.  (2007). Strategies for Primary HIV Prevention that target Behavioral Change. Clinical Infectious Diseases, 45(4), S300-S307.

Altice, F.L., Smith-Rohrberg, Maru D., Bruce, R.D., Springer, S.A., and Friedland, G.H.  (2007). Superiority of Directly Administered Antiretroviral Therapy over Self-Administered Therapy among HIV-Infected Drug Users: A Prospective, Randomized, Controlled Trial. Clinical Infectious Diseases, 45(6), 770-778.

Ravi, A., Blankenship, K.M., and Altice, F.L.  (2007). The Association between History of Violence and HIV Risk: A Cross-Sectional Study of HIV-Negative Incarcerated Women in Connecticut. Women's Health Issues, 17(4), 210-216.

2006

Smith-Rohrberg, D., Mezger, J., Walton, M., Bruce, R.D., and Altice, F.L.  (2006). Impact of Enhanced Services on Virologic Outcomes in a Directly Administered Antiretroviral Therapy Trial for HIV-Infected Drug Users. Journal of Acquired Immune Deficiency Syndromes, 43(s1), 88-95.

Altice, F.L., Sullivan, L.E., Smith-Rohrberg, D., Basu, S., Stancliff, S., and Eldred, L.  (2006). The Potential Role of Buprenorphine in the Treatment of Opioid Dependence in HIV-Infected Individuals and in HIV Infection Prevention. Clinical Infectious Diseases, 43(Suppl 4), S178-S183.

2005

Altice, F.L., Bruce, R.D., Walton, M.R. and Buitrago, M.I.  (2005). Adherence to Hepatitis B Virus Vaccination At Syringe Exchange Sites. Journal of Urban Health, 82(1), 151-161.

Altice, F.L., Marinovich A., Khoshnood K., Blankenship K.M., Springer S.A., and Selwyn P.A.  (2005). Correlates of HIV Infection among Incarcerated Women: Implications for Improving Detection of HIV Infection. Journal of Urban Health, 82(2), 312-326.

Resch, S., Altice, F.L., and Paltiel, A.D.  (2005). Cost-Effectiveness of HIV Screening for Incarcerated Pregnant Women. Journal of Acquired Immune Deficiency Syndromes, 38(2), 163-173.

Basu, S., Smith-Rohrberg, D., Hank, S., Altice, F.L.  (2005). HIV Testing in Correctional Institutions: Evaluating Existing Strategies, Setting New Standards. AIDS & Public Policy Journal, 20(1-2), 3-24.

2004

Springer, S., Pesanti, E., Hodges, J., Macura, T., Altice, F.L.  (2004). Effectiveness of Antiretroviral Therapy among HIV Infected Prisoners and the Lack of Sustained Benefit after Release to the Community. Clinical Infectious Diseases, 38(12), 1754-60.

Altice, F.L. and Bruce, R.D  (2004). Hepatitis C Virus Infection in United States Correctional Institutions. Current Hepatitis Reports, 3(3), 112-118.

Smith-Rohrberg, D., Bruce, R.D., and Altice, F.L.  (2004). Review of Corrections Based Therapy for Opiate-Dependent Patients: Implications for Buprenorphine Treatment Among Correctional Populations. Journal of Drug Issues, 34(2), 451-480.

2003

Altice, F.L., Springer, S., Buitrago, M., Hunt, D.P. and Friedland, G.H.  (2003). Pilot Study to Enhance HIV Care Using Needle Exchange-based Health Services for Out-of-treatment Injecting Drug Users. Journal of Urban Health, 80(3), 416-27.

2002

Broadhead, R.S., Heckathorn, D.D., Altice, F.L., van Hulst, Y., Carbone, M., Friedland, G.H., O'Connor, P.G. and Selwyn, P.A.  (2002). Increasing Drug Users' Adherence to HIV Treatment: Results of a Peer-Driven Intervention Feasibility Study. Social Science and Medicine, 55(2), 235-46.

Pollock, H.A., Khoshnood, K., Blankenship, K.M. and Altice, F.L.  (2002). The Impact of Needle Exchange-Based Health Services on Emergency Department Use. Journal of General Internal Medicine, 17(5), 341-348.

2001

Lazzarini, Z., Altice, F.L.  (2001). A Review of the Legal and Ethical Issues for the Conduct of HIV-Related Research in Prisons. AIDS & Public Policy Journal, 15(3), 103-125.

Altice, F.L., Mostashari, F. and Friedland, G.H.  (2001). Trust and the Acceptance of and Adherence to Antiretroviral Therapy. Journal of Acquired Immune Deficiency Syndromes, 28(1), 47-58.

1998

Altice, F.L., Mostashari, F., Checko, P., Singh, R., Tanquay, S.  (1998). Predictors of HIV Infection Among Newly-Sentenced Male Prisoners. JAIDS & HR, 18(5), 444-453.

Altice, F.L. and Friedland, G.H.  (1998). The Era of Adherence to HIV Therapy. Annals of Internal Medicine, 129(6), 503-5.

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